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KMUP-1 attenuates pro-inflammatory signaling (MAPKs signaling) induced by PgLPS in RANKL-primed pre-osteoclasts. The expression of pro-inflammatory mediators including (A,B) p-ERK/ERK, (C,D) p-p38/p38, and (E,F) p-JNK/JNK was analyzed in RANKL-primed pre-osteoclasts 30 min after PgLPS stimulation using western blot assay. n = 5. ###p < 0.001 compared with control; **p < 0.01, ***p < 0.001 compared with PgLPS.
