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. 2022 Apr 28;13:821492. doi: 10.3389/fphar.2022.821492

FIGURE 7.

FIGURE 7

KMUP-1 protects against periodontal bone loss induced by ligature placement. The periodontitis was induced by placement of ligature around the cervical region of the maxilla molar. (A) Representative micro-CT images of palatal maxilla of experimental groups. The distance between cementoenamel junction (CEJ) to alveolar bone crest (ABC) at (B) second maxillary molar (M2) of distolingual (DL) and (C) second maxillary molar (M2) of mesiolingual (ML) was measured (as denoted by red lines) 1 month after KMUP-1 treatment. (D) Representative cross-sectional micro-CT images of the first and second molar in the maxilla. Circles indicate region of interest. The volumetric parameters, including (E) bone volume/tissue volume (BV/TV), (F) trabecular thickness (Tb.Th), (G) trabecular separation (Tb.Sp), and (H) trabecular number (Th.N) were measured. (I) Representative image of TRAP stain in the maxillary alveolar bone sections. Arrows indicate TRAP+ cells. (J) Statistical analysis of osteoclast (TRAP+ cells) density in the maxillary alveolar bone. Scale bars: 100 μm n = 6. #p < 0.05, ##p < 0.01, ###p < 0.001 compared with sham. **p < 0.01, ***p < 0.001 compared with ligature.