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. 2022 Apr 28;13:821492. doi: 10.3389/fphar.2022.821492

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Copyright © 2022 Kuo, Zhang, Huang, Hsu, Wang, Nguyen, Lai and Yeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of molecular mechanism underlying inhibition of PgLPS-induced periodontitis by treatment of KMUP-1. PgLPS triggers pro-inflammatory reactions and thus promotes maturation of osteoclasts. Amplification of osteoclastogenesis leads to imbalance of bone remodeling which aggravates periodontitis progression. KMUP-1, through elevation of the cGMP-PKG pathway and reduction of pro-inflammatory signaling pathways, suppresses PgLPS-induced osteoclast differentiation thereby diminishing functional osteoclast maturation.