Table 5.
Risk of Adverse Events from Discharge Through 45 ± 14 Mutually-Exclusive Discharge Medication Groupings.
| Unadjusted | Adjusted | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
|
| ||||||
| Any adverse event | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 0.779 | 0.649–0.936 | 0.008 | 0.692 | 0.569–0.841 | 0<0.001 |
| DOAC and aspirin | 0.953 | 0.824–1.103 | 0.519 | 1.005 | 0.833–1.213 | 0.956 |
| DOAC | 0.772 | 0.630–0.945 | 0.012 | 0.731 | 0.574–0.930 | 0.011 |
| DAPT (P2Y12 and aspirin) | 1.038 | 0.805–1.339 | 0.772 | 1.044 | 0.790–1.378 |
0.763 |
| Any major adverse event | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 0.765 | 0.629–0.932 | 0.008 | 0.658 | 0.536–0.808 | <0.001 |
| DOAC and aspirin | 0.979 | 0.838–1.145 | 0.794 | 1.198 | 0.982–1.460 | 0.075 |
| DOAC | 0.739 | 0.597–0.914 | 0.005 | 0.767 | 0.597–0.985 | 0.038 |
| DAPT (P2Y12 and aspirin) | 1.026 | 0.778–1.353 | 0.8577 | 0.841 | 0.622–1.137 | 0.261 |
| Any readmissions | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 1.325 | 1.117–1.572 | 0.001 | 1.405 | 1.167–1.692 | <0.001 |
| DOAC and aspirin | 1.117 | 0.966–1.293 | 0.136 | 1.028 | 0.847–1.248 | 0.779 |
| DOAC | 1.331 | 1.100–1.612 | 0.003 | 1.275 | 1.004–1.617 | 0.046 |
| DAPT (P2Y12 and aspirin) | 1.062 | 0.818–1.380 | 0.650 | 1.042 | 0.785–1.383 | 0.777 |
| Any stroke or TIA | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 1.243 | 0.729–2.118 | 0.424 | 1.358 | 0.738–2.500 | 0.325 |
| DOAC and aspirin | 1.465 | 0.963–1.230 | 0.075 | 1.155 | 0.641–2.081 | 0.632 |
| DOAC | 1.285 | 0.732–2.256 | 0.382 | 0.947 | 0.460–1.948 | 0.882 |
| DAPT (P2Y12 and aspirin) | 1.418 | 0.688–2.921 | 0.344 | 1.615 | 0.704–3.705 | 0.258 |
| Device-related thrombus (among those with TEE) | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 0.825 | 0.599–1.136 | 0.239 | 0.754 | 0.502–1.133 | 0.174 |
| DOAC and aspirin | 0.997 | 0.768–1.295 | 0.985 | 1.057 | 0.702–1.592 | 0.791 |
| DOAC | 0.753 | 0.550–1.029 | 0.075 | 0.746 | 0.463–1.201 | 0.227 |
| DAPT (P2Y12 and aspirin) | 1.160 | 0.800–1.682 | 0.433 | 1.532 | 0.915–2.566 | 0.105 |
| Peridevice leak >5 mm (among those with TEE) | ||||||
| Warfarin and aspirin | Reference | |||||
| Warfarin | 0.675 | 0.412–1.106 | 0.118 | 0.671 | 0.401–1.124 | 0.129 |
| DOAC and aspirin | 0.721 | 0.480–1.084 | 0.116 | 0.795 | 0.474–1.333 | 0.384 |
| DOAC | 0.890 | 0.563–1.408 | 0.620 | 0.991 | 0.558–1.761 | 0.975 |
| DAPT (P2Y12 and aspirin) | 0.533 | 0.214–1.328 | 0.177 | 0.628 | 0.240–1.644 | 0.343 |