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. Author manuscript; available in PMC: 2023 May 10.
Published in final edited form as: J Am Coll Cardiol. 2022 May 10;79(18):1785–1798. doi: 10.1016/j.jacc.2022.02.047

Table 6.

Risk of Adverse Events from Discharge Through 6 Months In Mutually-Exclusive Discharge Medication Groupings.

Adverse event Unadjusted Adjusted
HR 95% CI P Value HR 95% CI P Value

Any adverse event
Warfarin and aspirin Reference
Warfarin 0.902 0.795–1.024 0.111 0.814 0.712–0.931 0.003
DOAC and aspirin 0.928 0.831–1.037 0.187 1.048 0.910–1.206 0.519
DOAC 0.826 0.719–0.949 0.007 0.863 0.730–1.021 0.085
DAPT (P2Y12 and aspirin) 1.017 0.836–1.236 0.868 0.979 0.791–1.212 0.847
Any major adverse event
Warfarin and aspirin Reference
Warfarin 0.915 0.807–1.037 0.164 0.840 0.737–0.958 0.010
DOAC and aspirin 0.918 0.823–1.023 0.121 1.098 0.956–1.260 0.187
DOAC 0.844 0.736–0.969 0.016 0.918 0.777–1.084 0.314
DAPT (P2Y12 and aspirin) 1.018 0.843–1.229 0.854 0.834 0.679–1.025 0.085
Any readmission
Warfarin and aspirin Reference
Warfarin 1.064 0.957–1.183 0.251 1.081 0.966–1.210 0.175
DOAC and aspirin 1.105 1.009–1.211 0.032 1.066 0.944–1.205 0.303
DOAC 1.155 1.030–1.295 0.014 1.146 0.994–1.321 0.061
DAPT (P2Y12 and aspirin) 1.067 0.906–1.257 0.435 1.061 0.887–1.269 0.517
Any stroke or TIA
Warfarin and aspirin Reference
Warfarin 1.108 0.807–1.521 0.527 1.129 0.801–1.591 0.489
DOAC and aspirin 1.298 1.003–1.680 0.048 1.051 0.751–1.470 0.772
DOAC 1.241 0.903–1.705 0.183 0.920 0.618–1.369 0.680
DAPT (P2Y12 and aspirin) 1.230 0.778–1.942 0.376 1.086 0.654–1.803 0.750

Abbreviations as in Table 1.