Table 3.
The diagnostic performance and the comparison between the diagnostic performance of CA125, hsa_circ_0003972 + CA125, hsa_circ_0007288 + CA125 and circCOMBO + CA125
| Best cut-off | AUC(95%CI) | Sensitivity (%) | Specificity (%) |
P-value | Comparison of AUC | ||
|---|---|---|---|---|---|---|---|
| Groups | P-value | ||||||
| CA125 | 38.825U/ml | 0.824(0.739–0.908) | 97 | 73 | p < 0.0001 | ||
| CA125 + circ-0003972 | − | 0.912(0.864–0.961) | 78.3 | 90.0 | NA | circ-0003972 vs. CA125 | 0.1201 |
| circ-0003972 vs. circ-0003972 + CA125 | p < 0.0001 | ||||||
| CA125 vs. circ-0003972 + CA125 | 0.0781 | ||||||
| CA125 + circ-0007288 | − | 0.918(0.869–0.968) | 98.3 | 71.7 | NA | circ-0007288 vs. CA125 | 0.5839 |
| circ-0007288 vs. circ-0007288 + CA125 | 0.0011 | ||||||
| CA125 vs. circ-0007288 + CA125 | 0.0613 | ||||||
| CA125 + circCOMBO | − | 0.923(0.878–0.968) | 80.0 | 93.3 | NA | circCOMBO vs. CA125 | 0.4947 |
| circCOMBO vs. circCOMBO + CA125 | p < 0.0001 | ||||||
| CA125 vs. circCOMBO + CA125 | 0.0449 | ||||||