Skip to main content
. 2022 Apr 4;12(8):4534–4544. doi: 10.1021/acscatal.1c05694

Figure 1.

Figure 1

Crystal structures of OXA-48 complexed with carbapenems. Acyl-enzyme (AC) structures of OXA-48 with IME (PDB ID 6P97, green sticks) and MER (PDB ID 6P98, light pink sticks) show a highly similar binding pose for both substrates, where main differences lie in the orientation of the carbapenem C2 “tail” group.1 The Ω-loop is highlighted in orange, the β5−β6-loop in yellow, and relevant active site interactions in dashed black lines. The carbapenem pyrroline ring is modeled as the Δ2-tautomer in both structures.