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. 2022 May 12;19:6. doi: 10.1186/s12950-022-00303-0

Fig. 1.

Fig. 1

Diagram of experimental groups and sequence of trauma injury patterns. Rats were randomly assigned to undergo blast (B), complex orthopaedic injury and ischemia reperfusion injury followed by hind limb amputation through the zone of injury (ZOI) (COI + IRI + HLA), B + COI + 1 h delayed (d) HLA, or B + COI + IRI + dHLA