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A large proportion of encapsulated proinflammatory mediators in the steady-state evade detection with conventional immunoassays. Serum compartmentalization of proinflammatory mediators in adult male naïve rats according to calculations of freely circulating (FC), exosome membrane-associated (MA), and exosome encapsulated (EC) levels. Results represent the mean ± SEM from n = 5-7 rats/timepoint
