Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 12;19:6. doi: 10.1186/s12950-022-00303-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 7 — The kinetics of circulating proinflammatory mediator levels and their biodistribution in serum compartments. Compartmentalization values over time post-injury were based on calculation of freely circulating (FC), exosome membrane-associated (MA), and exosome encapsulated (EC) levels following blast (B), complex orthopaedic injury and ischemia reperfusion injury followed by hind limb amputation (COI + IRI + HLA), B + COI + 1 h delayed (d) HLA, and B + COI + IRI + dHLA. Panel-A depicts interferon-gamma (IFN-γ), interleukin-1β (IL-1β), IL-10, IL-6, and chemokine (C-X-C motif) ligand 1 (CXCL1) levels in serum compartments. Panel-B depicts IL-13, IL-4, IL-5, and tumor necrosis factor-alpha (TNF-α) levels in serum compartments. Data are mean values ± SEM from n = 4-7 rats/timepoint. Baseline values are from age/weight matched naïve rats (n = 5-7)