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. 2022 Apr 28;13:879501. doi: 10.3389/fimmu.2022.879501

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Copyright © 2022 Guo, Wang, Wang, Guo, Cheng, Wang, Sun, Wang, Chang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRDM1 directly upregulated T cell inhibitory gene expression in primary T cells. (A) Aggregate plot of PRDM1 binding site around transcription start sites. (B) Locations of PRDM1 binding sites. (C) The overlap between PRDM1 target genes and differential expression genes in PRDM1-overexpressing T cells compared with control T cells. (D) Heatmap showed PRDM1 directly regulated differential expression genes in PRDM1-overexpressing T cells (OE group) compared with control T cells (CT group). FDR q-value < 0.05, |log₂fold change| > 1. (E) WashU browser views showed PRDM1 biding sites (CUT&Tag) and related gene expression level (RNA-seq). (F) Top 7 enriched transcription factor motifs in the PRDM1 CUT&Tag peaks are shown.