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. 2022 Apr 28;12:861807. doi: 10.3389/fonc.2022.861807

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Copyright © 2022 Wang, Huo, Zhang, Chen, Zhao, Shi, Xu and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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METTL3 decreased ADAMTS9 mRNA stability through m6A-YTHDF2 dependent pathway. (A) The regulation of METTL3 on ADAMTS9 m6A modification was evaluated in different GC cells. (B) The post-transcription level of ADAMTS9 was detected in METTL3-knockdown GC cells by using firefly luciferase reporter assay. (C) The level of ADAMTS9 mRNA was detected in YTHDF2 knockdown GC cells by qRT-PCR. (D) ADAMTS9 mRNA was analyzed at indicated times in METTL3 knockdown and control AGS cells with Act-D treatment. (E) RIP-qPCR assay was used to detect the enrichment of YTHDF2 binding to ADAMTS9 m6A modification sites. *P < 0.05, **P < 0.01, ***P < 0.001.