Table 1.

Criteria used by the included studies for symptomatic intracranial hemorrhage definition.

Trial	Criteria
ECASS II	Neurological deterioration, regardless of causal factor, or adverse events indicating clinical worsening or causing of increase in NIHSS score of >4 points
ECASS III	Clinical deterioration, predominantly caused by hemorrhage, defined by an increase of >4 points in NIHSS score or led to death
Heidelberg classification scheme	Clinical deterioration defined by an increase of >4 points in NIHSS score at time of diagnosis compared with immediately before worsening or ≥2 points in 1 NIHSS category, or leading to intubation, hemicraniectomy, ventricular rain placement, or other major medical/surgical intervention

ECASS, European Cooperative Acute Stroke Study; NIHSS, National Institute of Health Stroke Scale.