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. 2022 Apr 28;9:849005. doi: 10.3389/fnut.2022.849005

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Copyright © 2022 Lakshmanan, Al Zaidan, Bangarusamy, Al-Shamari, Elhag and Terranegra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gut microbial markers and their validation in the CVD risk group. (A) Gut microbial markers were measured by LEfSe analytical tool with an LDA cut-off value of >2.0 in both the CVD no-risk and CVD risk groups. (B,C) Gut microbial markers from LEfSe analysis were validated using the SIAMCAT tool, which displayed the cross-validation error as a receiver operating characteristic (ROC) curve with the 95% confidence interval shaded in gray. The area under the ROC (AUROC = 0.733) is given below the curve. The x-axis and y-axis represent false-positive and true-positive rates, respectively, for the tested markers. An AUROC value of more than 0.7 is considered fairly good in terms of the test's discriminative ability. CVD no-risk, N = 36; CVD risk, N = 10. “g_UC”: unclassified bacteria at the genus level.