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. 2022 Apr 28;12:866293. doi: 10.3389/fonc.2022.866293

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Copyright © 2022 Zhou, Zhou, Xiao, Wang, Wang, Shi, Yue, Jia, Li, Hu, Yang, Jiang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profiles for ER of available IHC results and CTCs. (A) Concordance/discordance in the expression of ER between CTCs and corresponding primary tumors. (B) Concordance/discordance in the expression of ER between CTCs and corresponding metastatic IHC results. (C) Distribution of ER in CTCs and corresponding IHC results of the patients with available samples. (D) The area under the curve under the assumption that the accuracy of ER detection by IHC was 100%. (E) The optimal threshold on the basis of precision-recall curve suggested that at least one ER-positive CTC within 2 ml of blood be defined as CTC^ER+.