Figure 3.

Hippocampal functional connectivity predicts number sense training gains. A, B, Functional connectivity before training of the left and right hippocampal ROIs, selected from Brainnetome (Fan et al., 2016) parcellations, with the left IPS positively (red) predicted learning (efficiency gains in symbolic quantity discrimination) in the training group. Hippocampal connectivity with the left cuneus was negatively (blue) correlated with learning. C, Conjunction analysis of functional connectivity patterns revealed the left IPS and the left cuneus to be an overlapping target region across the left and right hippocampal seed-to-whole-brain connectivity positively (red) and negatively (blue) associated with learning, respectively, in the training group. D, In TD children in the training group, hippocampal functional connectivity with the left IPS was positively associated with learning (red) and that with the left cuneus was negatively associated with learning (blue). In children with MLD in the training group, conjunction analysis did not yield any overlapping target region across the left and right hippocampal seed-to-whole-brain functional connectivity associated with learning. L, Left; R, right.