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. Author manuscript; available in PMC: 2023 Feb 10.
Published in final edited form as: Annu Rev Physiol. 2021 Oct 6;84:257–283. doi: 10.1146/annurev-physiol-062421-040656

Figure 4.

Figure 4

Cardiomyocyte-directed transport. (a) Subway map of microtubule-based transport in cardiomyocytes. Anterograde pathways are displayed in orange and retrograde pathways in blue. Nodes represent specific organelles, and green microtubules represent segments where microtubules are reported to be involved in trafficking. (b) Search and capture of microtubules in cardiomyocytes. Microtubules growing from microtubule organizing centers have a plus-end that extends outward. If the plus-end-associated proteins fail to find an interaction partner, the microtubule is susceptible to catastrophe and will repeat the growth process. If the microtubule finds a binding partner, the microtubule is protected from depolymerization and forms a stable, long-lived microtubule track. The table lists known/putative plus-end proteins and their interaction partner that forms an anchor for the microtubule for different cardiomyocyte membrane domains. Abbreviations: ER, endoplasmic reticulum; SR, sarcoplasmic reticulum.