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CD4+ T-cell subsets and their role on the final manufactured chimeric antigen receptor T-cell (CAR-T cell) product. Different environment cytokine combinations are required to generate different CD4+ T-cell subsets. Characteristics of T helper 9 (Th9) and Th17 cells with the potential to improve the efficacy of CAR-T cells and the role of regulatory T cells (Tregs) as indicators of therapeutic efficacy are shown.
