Figure 4.

KL1 increases synaptic plasticity. A, Experimental paradigm of hippocampal LTP recordings from male mice (age, 3 months) treated with vehicle (Veh) or KL1 (mouse or human form: 10 μg/kg, s.c.). B, fEPSP recordings from acute hippocampal slices of mice treated with vehicle or mouse KL1 (n = 19 slices from five mice for vehicle; 9 slices from three mice for mKL1). C, Average fEPSP slope of the last 10 min (Mins) of each recording for vehicle- and mKL1-treated mice. *p = 0.0377, df = 26 (two-tailed t test). Values represented are data ± SEM. D, fEPSP recording from acute hippocampal slides of mice treated with vehicle or hKL1 (n = 10 slices from three mice for vehicle; 8 from three mice for hKL1). E, Average fEPSP slope of the last 10 min of each recording for vehicle- and hKL1-treated mice. *p = 0.0285, df = 16. Values represented are data ± SEM Veh, vehicle. mKL1, mouse KL1. hKL1, human KL1.