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. 2022 May 11;42(19):3919–3930. doi: 10.1523/JNEUROSCI.2416-21.2022

Figure 6.

Figure 6.

Characteristics of persistent D2ICs in SNc DA neurons from Syt7 KO mice. A, Stability of phasic D2ICs in SNc DA neurons from Syt7 KO mice recorded in 2.4 mm [Ca2+]o. B, Representative D2ICs after establishing whole-cell recording (initial) and at the end of the recording period (final). C, Quantification of D2IC amplitude (final: 93 ± 14% of initial, n = 4; p = 0.95, unpaired t test). D, Time to peak (WT: 253 ± 13 ms, n = 18; KO: 251 ± 9 ms, n = 21; p = 0.93, unpaired t test). E, Half-width (WT: 424 ± 15 ms, n = 18; KO: 425 ± 16 ms, n = 21; p = 0.98, unpaired t test). F, Decay time constant (WT: 394 ± 21 ms, n = 16; KO: 429 ± 24 ms, n =19; p = 0.32, unpaired t test). G, Quinpirole-evoked D2 currents (WT: 43.7 ± 5.3 pA, n = 9; Syt7 KO: 41.6 ± 5.2 pA, n = 10; p = 0.79, paired t test). H, Spontaneous activity (WT: 2.8 ± 0.2 Hz, n = 19; Syt7 KO: 2.9 ± 0.2 Hz, n = 26; p = 0.75, unpaired t test). I, h-current (WT: 0.89 ± 0.09 nA, n = 14; Syt7 KO: 0.93 ± 0.07 nA, n = 26; p = 0.72, unpaired t test). J, Cell capacitance (WT: 33.1 ± 1.7 pF, n = 19; Syt7 KO: 35.1 ± 1.4 pF, n = 26; p = 0.35, unpaired t test). K, Input resistance (WT: 293.9 ± 22.1 MΩ, n = 19; Syt7 KO: 255.8 ± 16.5 MΩ, n = 26; p = 0.17, unpaired t test). L, Series resistance (WT: 8.4 ± 0.8 MΩ, n = 19; Syt7 KO: 9.7 ± 0.4 MΩ, n = 26; p = 0.14, unpaired t test). n.s., Not significant.