TABLE 1.
Roles of fucosylation in normal cellular/organ development and biology versus cancer
| Organ/tissue | Normal cell/organ biology | FUTs | References (PMID) |
Cancer | FUTs | References (PMID) |
|---|---|---|---|---|---|---|
| Peripheral blood | FUT4 | 31097000 | ||||
| 24838610 | POFUT1 | 30344988 | ||||
| Leukocyte trafficking and homing | FUT1/2 | 8752218 | Myeloid leukemia | 20645416 | ||
| FUT4/7 | 8822932 | FUT8 | 27967290 | |||
| 11485743 | Lymphoma | - | 23493549 | |||
| MM | - | 30844485 | ||||
| Breast | - | - | - | Breast cancer | FUT1 | 27560716 |
| 27375041 | ||||||
| FUT4 | 23887626 | |||||
| 26701615 | ||||||
| 28692034 | ||||||
| FUT8 | 28982386 | |||||
| Lung | Pulmonary development | FUT8 | 16236725 | NSCLC | FUT4 | 32629386 |
| 31104223 | ||||||
| FUT7 | 28860805 | |||||
| FUT8 | 26443198 | |||||
| 23267084 | ||||||
| Liver | Hepatic development | FUT2 | 28056490 | Hepatocellular carcinoma | FUT4/6/8 | 24232099 |
| FUT7 | 11935309 | |||||
| 15666088 | ||||||
| FUT8 | 23352314 | |||||
| Brain | Synapse formation and neurite outgrowth | FUT1/2 | 15686343 | Glioblastoma | 29669750 | |
| FUT8 | 25727145 | |||||
| Gastrointestinal system | 33323540 | |||||
| Host–microbe interactions | FUT2 | 17673542 | Gastric cancer | FUT3/5 | 21978830 | |
| Gut microbiome maintaining | FUT3 | 25263220 | FUT8 | 24732908 | ||
| 25274297 | Colorectal cancer | FUT1 | 17459061 | |||
| 28988527 | FUT3/5/6 | 24253505 | ||||
| 28771224 | ||||||
| POFUT1 | 30250219 | |||||
| 9000578 | ||||||
| Skin | Keratinocyte migration (differentiation and epidermis renewal) | FUT1 | 23625752 | Melanoma | FUT1 | 29924834 |
| 17897065 | ||||||
| FUT4 | 25672851 | |||||
| 31961483 | ||||||
| FUT8 | 28609658 | |||||
| Prostate | Origination of Lewis/Core-type Fuco-PSAs | FUT3/8 | 27494861 | Prostate cancer | FUT3/6/7 | 24178760 |
| FUT8 | 24906821 | |||||
| Pancreatic | Lewis b, Lewis y, and H-type antigens | FUT1/2 | 10728712 | Pancreatic cancer | FUT1 | 10728712 |
| FUT3 | 11058871 | |||||
| 29963165 | ||||||
| Oral/head and neck | - | - | - | Oral squamous cell carcinoma | FUT1 | 23242548 |
| FUT3/6 | 25428916 | |||||
| Ovary | 29130097 | |||||
| FUT1 | 20003467 | |||||
| - | - | - | Ovarian cancer | 27240592 | ||
| FUT8 | 11093814 |
Abbreviations: FUT, fucosyltransferase; MM, multiple myeloma; NSCLC, non-small cell lung cancer; POFUT, protein O-fucosyltransferase; PSA, prostate-specific antigen.