Figure 3.

The 11LNCPS scores predict immune responses in HCC. (A) Increased infiltrations of Th1, Th2, and pro B cells are associated with worse OS, while that of CD8+ Tcm, CD8+ T, and pDC cells with better OS in HCC, as determined by the Kaplan-Meier analysis. (B) The infiltration level is different (P < 0.05) between HCCs with higher 11LNCPS scores (red) and lower scores (blue) for 10 types of immune cells. (C, D) HCCs with higher 11LNCPS scores have higher TCE scores (C) and lower T cell dysfunction scores (D). (E) Higher 11LNCPS scores are associated with better therapeutic responses to immune checkpoint inhibitors (ICIs) in HCC patients. Nominal and Bonferroni corrected P values are shown for the correlation between 11LNCPS scores and ICI responses (CTAL4, PD1, and PD-L1). noR, non-responder; R, responder. Grid colors indicate the correlation P values.