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. 2022 Apr 28;13:880288. doi: 10.3389/fimmu.2022.880288

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Copyright © 2022 Li, Zhang, Liu, Fu, A, Chen, Wu and Dong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of LINC01134 and AC116025.2 is associated with the expression of some cytokines, chemokines, and immune checkpoint (ICP) ligands in HCC. (A) The chord diagram shows heterotypic signal transduction between HCC cells (purple) and CD8+ T cells (green), with purple arrows pointing from cytokines and chemokines (left) or ICP ligands (right) in HCC cells to their respective receptors in CD8+ T cells. (B, C) Expression of LINC01134 (B) and AC116025.2 (C) is associated with the expression of some cytokines and chemokines (left) or ICP ligands (right), as determined by the Spearman analysis. Grid colors and gradient color bars indicate Spearman coefficient values, with white color indicating a lack of statistical significance. Cytokines, chemokines, and ICP ligands with a positive association with LINC01134 or AC116025.2 expression are marked by red, while those with a negative correlation are marked by blue.