Table 4.
Classification and AUC metrics for APP, HSPB1, and age features.
| Datasets | % Non-Hispanic White | APP | APP + HSPB1 | APP + Age | All 3 |
|---|---|---|---|---|---|
| MSBB-Full | 76.8% | ||||
| AUC | 0.89 | 0.93 | 0.90 | 0.93 | |
| NHW % error | 15 | 13 | 13 | 14 | |
| AA % error | 30 | 22 | 30 | 22 | |
| H % error | 24 | 6 | 18 | 6 | |
| ROSMAP | 98.4% | ||||
| AUC | 0.89 | 0.91 | 0.92 | 0.93 | |
| NHW % error | 13 | 11 | 12 | 12 | |
| AA % errora | 33 | 33 | 33 | 33 | |
| Pitt ADRC-Hippocampus | 55.6% | ||||
| AUC | 0.76 | 0.89 | 0.90 | 0.91 | |
| NHW # error | 2 | 3 | 3 | 3 | |
| AA # error | 1 | 1 | 1 | 0 | |
| Pitt ADRC-IPL | 52.6% | ||||
| AUC | 0.89 | 0.98 | 0.89 | 0.96 | |
| NHW # error | 0 | 2 | 0 | 1 | |
| AA # error | 1 | 1 | 1 | 1 |
a
33% of the African American/Black participants is equal to one sample. The AUCs from classification with APP alone and APP + HSPB1 were compared using DeLong’s test, resulting in the following p-values: MSBB-Full, p = 0.01; ROSMAP, p = 0.09; Pitt ADRC-hippocampus, p = 0.20; Pitt ADRC-IPL, p = 0.39.
Abbreviations: AA, African American/Black; APP, amyloid-β precursor protein; H, Hispanic; HSPB1, heat shock protein β-1; MSBB, Mount Sinai Brain Bank; NHW, non-Hispanic White; ROSMAP, Religious Orders Study and Rush Memory and Aging Project; Pitt ADRC, University of Pittsburgh Alzheimer Disease Research Center; IPL, inferior parietal lobule.