TABLE 2a.

Clinical observations—female rats.

	REL-1017				Methadone	MK-801	p
	Dose (mg/kg/d)
	0	20	40	80	20	2
Number of animals	15	15	15	15	15	15	(MK801 vs. all)
Behavior/activity
Activity decreased
Number of times recorded	0	0	0	0	2	47	—
Number of animals affected	—	—	—	—	2	15	<0.0001
Ataxia
Number of times recorded	0	0	0	0	0	28	—
Number of animals affected	—	—	—	—	—	10	<0.0001
Lateral recumbency
Number of times recorded	0	0	0	0	0	3	—
Number of animals affected	—	—	—	—	—	3	<0.05
Salivation
Number of times recorded	0	0	0	0	0	1	—
Number of animals affected	—	—	—	—	—	1	ns
Ventral recumbency
Number of times recorded	0	0	0	0	2	20	—
Number of animals affected	—	—	—	—	2	14	<0.0001
External Appearance
Limb function impaired
Number of times recorded	0	0	0	0	4	48	—
Number of animals affected	—	—	—	—	1	10	<0.0001
Material around eyes, black
Number of times recorded	0	0	0	0	0	5	—
Number of animals affected	—	—	—	—	—	3	<0.05
Material around eyes, red
Number of times recorded	0	0	1	0	0	11	—
Number of animals affected	—	—	1	—	—	4	<0.05
Material around nose, black
Number of times recorded	0	0	0	0	0	2	—
Number of animals affected	—	—	—	—	—	2	ns
Material around nose, red
Number of times recorded	0	1	0	1	0	5	—
Number of animals affected	—	1	—	1	—	5	<0.01
Thin
Number of times recorded	0	1	1	1	1	24	—
Number of animals affected	—	1	1	1	1	8	<0.0001
Pelage/Skin
Hair wet
Number of times recorded	0	0	0	0	0	3	—
Number of animals affected	—	—	—	—	—	2	ns
Skin discoloured, red
Number of times recorded	0	0	0	0	0	5	—
Number of animals affected	—	—	—	—	—	1	ns
Skin discoloured, red/black
Number of times recorded	0	0	0	0	0	1	—
Number of animals affected	—	—	—	—	—	1	ns
Behaviour/activity
Righting reflex impaired
Number of times recorded	0	0	0	0	0	7	—
Number of animals affected	—	—	—	—	—	7	<0.0001