TABLE 2b.

Clinical observations—Male rats.

	REL-1017				Methadone	MK-801	p
	Dose (mg/kg/d)
	0	20	40	80	20	2
Number of animals	15	15	15	15	15	15	(MK801 vs. all)
Behaviour/activity
Activity decreased
Number of times recorded	0	0	0	0	0	40	—
Number of animals affected	—	—	—	—	—	12	<0.0001
Ataxia
Number of times recorded	0	0	0	0	0	23	—
Number of animals affected	—	—	—	—	—	13	<0.0001
Salivation
Number of times recorded	0	0	0	0	0	15	—
Number of animals affected	—	—	—	—	—	12	<0.0001
Trembling
Number of times recorded	0	0	0	0	0	6	—
Number of animals affected	—	—	—	—	—	5	<0.0001
Ventral recumbency
Number of times recorded	0	0	0	0	0	11	—
Number of animals affected	—	—	—	—	—	9	<0.0001
External Appearance
Limb function impaired
Number of times recorded	0	0	0	0	0	62	—
Number of animals affected	—	—	—	—	—	10	<0.0001
Material around eyes, red
Number of times recorded	0	0	0	0	0	4	—
Number of animals affected	—	—	—	—	—	3	<0.001
Material around nose, red
Number of times recorded	0	0	1	0	0	0	—
Number of animals affected	—	—	1	—	—	—	ns
Pelage/Skin
Hair, sparse
Number of times recorded	0	0	0	2	3	0	—
Number of animals affected	—	—	—	1	1	—	ns
Hair, wet
Number of times recorded	0	0	0	0	0	6	—
Number of animals affected	—	—	—	—	—	6	<0.0001
Scabbed area
Number of times recorded	0	0	1	0	0	0	—
Number of animals affected	—	—	1	—	—	—	ns