TABLE 3.
Body weight of animals during the study.
| REL-1017 | Methadone | MK-801 | ||||
|---|---|---|---|---|---|---|
| Dose (mg/kg/day) | 0 | 20 | 40 | 80 | 20 | 2 |
| Female a | ||||||
| Day 1 | 236.6 ± 10.89 (N = 15) | 231.3 ± 13.66 (N = 15) | 239.7 ± 10.65 (N = 15) | 238.7 ± 10.12 (N = 15) | 237.8 ± 9.80 (N = 15) | 236.0 ± 21.30 (N = 15) |
| Day 1 (sacrifice) | 237.7 ± 12.27 (N = 5) | 230.5 ± 13.68 (N = 5) | 241.7 ± 12.97 (N = 5) | 236.1 ± 9.93 (N = 5) | 240.1 ± 8.9 (N = 5) | 232.5 ± 21.80 (N = 5) |
| Day 3 (sacrifice) | 223.0 ± 9.70 (N = 5) | 220.6 ± 8.91 (N = 5) | 227.0 ± 6.28 (N = 5) | 216.8 ± 4.49 (N = 5) | 230.6 ± 9.81 (N = 5) | 219.0 ± 25.60 (N = 5) |
| Day 5 (sacrifice) | 229.4 ± 15.13 (N = 5) | 221.6 ± 23.64 (N = 5) | 230.6 ± 19.11 (N = 5) | 218.4 ± 9.40 (N = 5) | 229.0 ± 2.94 (N = 4) | 218.6 ± 16.26 (N = 5) |
| Dose (mg/kg/day) Male a | 0 | 31.25 | 62.5 | 110 | 31.25 | 5 |
| Day 1 | 346.4 ± 14.03 (N = 15) | 344.7 ± 14.06 (N = 15) | 342.5 ± 10.93 (N = 15) | 351.3 ± 16.23 (N = 15) | 341.1 ± 15.38 (N = 15) | 341.7 ± 16.55 (N = 15) |
| Day 1 (sacrifice) | 350.0 ± 14.81 (N = 5) | 347.9 ± 14.07 (N = 5) | 344.9 ± 12.57 (N = 5) | 353.3 ± 18.09 (N = 5) | 350.9 ± 16.12 (N = 5) | 334.4 ± 15.55 (N = 5) |
| Day 3 (sacrifice) | 342.2 ± 12.4 (N = 5) | 328.4 ± 15.76 (N = 5) | 332.6 ± 7.23 (N = 5) | 333.0 ± 16.99 (N = 5) | 325.6 ± 17.60 (N = 5) | 318.4 ± 14.69 (N = 5) |
| Day 5 (sacrifice) | 353.0 ± 20.46 (N = 5) | 349.4 ± 15.88 (N = 5) | 352.0 ± 14.30 (N = 5) | 345.0 ± 12.91 (N = 4) | 340.8 ± 8.73 (N = 4) | 327.2 ± 18.46 (N = 5) |
a
Data are expressed in grams (mean ± SD).