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. 2022 Apr 25;13:863959. doi: 10.3389/fphar.2022.863959
Vacuolation
Severity Grade 1 (minimal) One or a few foci (or affected cells) present
Severity Grade 2 (mild) More than a few foci (or affected cells) present
Severity Grade 3 (moderate) Focally extensive to more diffuse area/groups of cells affected
Severity Grade 4 (marked) Prominent portion of the tissue and/or cell type affected
Severity Grade 5 (severe) Greater than 40% of the region/cells affected