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. 2022 Apr 25;13:863959. doi: 10.3389/fphar.2022.863959
Migrogliosis
Severity Grade 1 (minimal) Microgliosis barely exceeds normal limits; it is typically focal and/or sporadic and of no biological relevance; it is a common change in control animals, especially monkeys
Severity Grade 2 (mild) Microgliosis more readily apparent than minimal severity grade, typically focal or multifocal; typically a level of severity uncommonly encountered in controls
Severity Grade 3 (moderate) Microgliosis readily apparent; typically focally extensive or multifocal and typically a level of severity uncommonly encountered in controls
Severity Grade 4 (marked) Microgliosis pronounced, affecting a prominent portion of a given brain/spinal cord region, typically at a level of severity not encountered in controls
Severity Grade 5 (severe) Microgliosis very pronounced, affecting a prominent portion of a given brain/spinal cord region, typically at a level of severity not encountered in controls