TABLE 2.

Two-by-two contingency table for disproportional analysis.

	DILI	All other adverse drug reactions	Total
Antifungal drugs	a	c	a + c
All other drugs	b	d	b + d
Total	a + b	c + d	a+b + c + d

ROR = (a/b)/(c/d), $95\%\mathrm{CI}={\mathrm{e}}^{\ln \left(\mathrm{ROR}\right)\pm 1.96\left(1/\mathrm{a}+1/\mathrm{b}+1/\mathrm{c}+1/\mathrm{d}\right)^0.5}\left(\mathrm{criteria}:95\%\mathrm{CI}>1,\mathrm{n}\ge 2\right)$ ;

PRR = (a / [a + c]) / (b / [b + d]), ${\mathrm{\chi }}^2=\Sigma \left(\left[\mathrm{O}-\mathrm{E}\right]^2/\mathrm{E}\right)\text{,}\left(\mathrm{O}=\mathrm{a,}\mathrm{E}=\left[\mathrm{a}+\mathrm{b}\right]\left[\mathrm{a}+\mathrm{c}\right]/\left[\mathrm{a}+\mathrm{b}+\mathrm{c}+\mathrm{d}\right]\right)\left(\mathrm{criteria:PRR}\ge 2,{\chi }^2\ge 4,\mathrm{n}\ge 3\right)$ ; $\mathrm{IC}=\log 2\mathrm{a*}\left(\mathrm{a}+\mathrm{b}+\mathrm{c}+\mathrm{d}\right)/\left(\left[\mathrm{a}+\mathrm{c}\right]\left[\mathrm{a}+\mathrm{b}\right]\right),\mathrm{IC}025={\mathrm{e}}^{\ln \left(\mathrm{IC}\right)-1.96\left(1/\mathrm{a}+1/\mathrm{b}+1/\mathrm{c}+1/\mathrm{d}\right)^0.5}\left(\mathrm{criteria:IC}025>0\right)$ ;

$\mathrm{EBGM}=\mathrm{a*}\left(\mathrm{a}+\mathrm{b}+\mathrm{c}+\mathrm{d}\right)/\left(\left[\mathrm{a}+\mathrm{c}\right]\left[\mathrm{a}+\mathrm{b}\right]\right),\mathrm{EBGM}05={\mathrm{e}}^{\ln \left(\mathrm{EBGM}\right)-1.64\left(1/\mathrm{a}+1/\mathrm{b}+1/\mathrm{c}+1/\mathrm{d}\right)^0.5}\left(\mathrm{criteria}:\mathrm{EBGM}05\ge 2,\mathrm{n}>0\right)$ .

CI, indicates confidence interval; n, indicates the number of co-occurrences; χ2, indicates chi-squared; IC, indicates information component; IC025, indicates the lower limit of the 95% two-sided CI of the IC; EBGM05, the lower limit of the 90% one-sided CI of the EBGM.