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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Acc Chem Res. 2022 Jan 18;55(3):381–390. doi: 10.1021/acs.accounts.1c00648

Figure 3: Visualizing the misfolded oligomers using the AggTag method.

Figure 3:

(A) Overview of the AggTag method. (B) Chemical modulation of the FP chromophore (HBI) to detect protein aggregation. (C) Chemical structure of 3. (D) 3 detects misfolded oligomers during α-synuclein aggregation. (E) Chemical structure of 3h. (F–G) Detecting misfolded oligomers of Htt (F) and SOD1-V31A (G). Reproduced with permission from Ref. 2. Copyright 2018 American Chemical Society.