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. 2022 May 5;2022:3435267. doi: 10.1155/2022/3435267

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Copyright © 2022 Heng Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Minocycline reduced neuroinflammation after ICH in vitro. (a) Minocycline reduced the protein levels of IL17, IL21, IL22, TGFβ, TNFα, and IFNγ after hemoglobin stimulation. (b) Changes of IL17, IL21, IL22, TGFβ, TNFα, and IFNγ mRNA levels in the T cell + OPCs group, T cell + OPCs + Mino group, T cell + OPCs + hemoglobin group, and T cell + OPCs + hemoglobin + Mino group. ^∗ ^∗P < 0.01, ^∗ ^∗ ^∗P < 0.001, ^∗ ^∗ ^∗ ^∗P < 0.0001 vs. the T cell + OPCs group; ^##P < 0.01, ^####P < 0.0001 vs. the T cell + OPCs + hemoglobin group.