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. 2022 Apr 29;23(5):731–742. doi: 10.1038/s41590-022-01187-1

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Intracellular staining (ic) of Foxp3 in CD4 and CD8 T cells among TCRβ^hi thymocytes from B6 and FlipFlop mice (left). Bar graph shows numbers of Foxp3⁺ T cells. (mean+s.e.m., n=5/strain, representative of 5 independent experiments). (b) Treg-associated protein expression in B6 CD4 and FlipFlop CD8 helper-lineage T cells. (mean+s.e.m., n=5/strain, representative of 5 independent experiments). (c) Impact of the Scurfy mutation on B6 and FlipFlop LN T cells. (n=3/strain, representative of 3 independent experiments). (d) In vitro stimulation of CD40L and CD69 surface expression on B6 and FlipFlop LN T cells by medium (gray bar) or by immobilized anti-TCRβ+CD28 mAbs for 24 h (n=3/strain, 3 independent experiments). (e) Kinetics of skin allograft rejection.