Table 2.

Clinical milestones as time-dependent covariate risk factors and time to death.

	Time to death, median (IQR)	Adjusted HR (95% CI)	p value
Falls	6.2 (3.6–8.9)	3.58 (2.02–6.33)	<0.001
Hallucinations	6.0 (4.3–7.7)	2.16 (1.26–3.71)	0.004
PDD	4.4 (3.6–5.1)	2.86 (1.59–5.13)	0.004
NHP	2.8 (2.3–3.2)	3.03 (1.65–5.52)	<0.001
Cumulative clinical milestones
One clinical milestone	6.2 (5.9–8.2)	2.24 (1.02–4.93)	0.043
Two clinical milestones	4.0 (3.0–6.3)	4.04 (1.78–9.18)	<0.001
Three clinical milestones	2.9 (2.3–NAa)	4.53 (1.76–11.62)	0.002
Four clinical milestones	2.3 (1.7–NAa)	10.83 (4.39–26.73)	<0.001

Bold values are statistically significant. p < 0.05.

PDD Parkinson’s disease dementia, NHP nursing home placement, IQR interquartile range, HR hazard ratio, CI confidence interval.

^aMore than 25% of patients who had experienced this many milestones were still alive at end-of-study.