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. 2022 May 12;12:7793. doi: 10.1038/s41598-022-11931-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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GFI1 and ATOH1 bind to many common genomic sites in hair cells. (a) De novo motif analysis of 732 GFI1 binding loci. Of note, the most significantly enriched motifs in the GFI1-bound peaks are for SIX, POU and bHLH protein families, with zinc finger family protein motifs (of which GFI1 is a member) are only found in 8.15% of targets. (b) Venn diagram of the peaks obtained in CUT&RUN experiments for GFI1 and ATOH1 binding, showing 386 overlapping loci that are bound by both GFI1 and ATOH1. (c) Heat map showing individual called peaks from GFI1 and ATOH1 CUT&RUN analysis shown in B. (d) Gene ontology analysis of and the 341 ATOH1 and GFI1 co-bind genes. (e) Gene ontology analysis of the 309 GFI1 uniquely binding genes.