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. 2022 May 12;12:7793. doi: 10.1038/s41598-022-11931-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Examples of hair cell and non-hair cell enriched genes that are bound and regulated by GFI1 and ATOH1. (a) Genomic browser tracks of RNA-seq and CUT&RUN sequencing of two hair cell genes containing both ATOH1 and GFI1 binding sites that are up-regulated in the Gfi1 knockout: Atoh1 (Log₂ fold change in homozygous (homo) vs. heterozygous (het) Gfi1 mutants (LFC) = 0.42; False discovery rate (FDR) = 0.0492) and Nefm (LFC = 0.84; FDR = 0.000127). Box shows a peak that is uniquely bound by GFI1. (b) Genomic browser tracks of RNA-seq and CUT&RUN sequencing of two hair cell genes containing both ATOH1 and GFI1 binding sites that are down-regulated in the Gfi1 knockout: Rbm24 (LFC = − 0.85; FDR = 5.25E−07) and Scn11a (LFC = − 0.5; FDR = 0.00245). Box shows a peak that is uniquely bound by ATOH1. (c) Genomic browser tracks of RNA-seq and CUT&RUN sequencing of neuronal (non-hair cell) genes containing both ATOH1 and GFI1 binding sites that are upregulated in the Gfi1 knockout: Cntnap2 (LFC = 2.59; FDR = 3.79E−32) and Cntnap5a (LFC = 0.79; FDR = 6.23E−05). Boxes show peaks that are uniquely bound by Gfi1.