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. 2022 May 12;12:7896. doi: 10.1038/s41598-022-12035-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A proposed model of alcohol-induced changes in functional connectivity. In basal states, pyramidal neurons are inhibited by GABAergic interneurons, which leads to balanced transmissions. After drinking a moderate dose of alcohol, the activity of SST-expressing interneurons is disrupted, resulting in disinhibition, hyperexcitability, and increased functional connectivity only in SST-sparse regions. HTR3A 5-hydroxytryptamine 3a receptor, GABA gamma-aminobutyric acid, PN pyramidal neuron, PVALB parvalbumin, SST somatostatin.