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. 2022 May 12;13:2638. doi: 10.1038/s41467-022-30303-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Screening of DNA damage repair-related proteins that undergo LLPS. Details could be found in Supplementary Figure 1a. b MRNIP-GFP showed puncta in the nucleus of HEK 293 T cells. HEK 293 T cells were transfected with plasmid for 24 h before observation. c Immunofluorescence of endogenous MRNIP in HCT8 and HeLa cells. d Immunofluorescence assay showing that MRNIP formed puncta in 3 out of 6 CRC tissues. Frozen sections of CRC tissues were analyzed using Immunofluorescence assay. e MRNIP protein was upregulated in CRC tissues. Twenty-seven CRC tissues and adjacent normal tissues were analyzed. f, g Higher MRNIP expression was correlated with shorter survival time of CRC patients. The correlations were analyzed with Kaplan-Meier curve and Log-rank test. h CRC patients with higher MRNIP level were more resistant to radiotherapy. TRG, Tumor regression grade. For (f–h), CRC tissues from 213 patients were analyzed. i, j Xenograft model showed that MRNIP depletion sensitized tumor cells to radiation. For (j), each line represents one xenograft.