Fig. 1.

Minimal important differences obtained using the mean change method and generalized estimating equations. Symptom scales were reversed to align with functional scales; therefore, positive values represent decreases in symptom scales. Absence of the line (e.g., GEE estimates for deterioration in PF) indicates that no minimal important difference estimate that met our criteria was obtained. GEE generalized estimating equation; QL global quality of life; PF physical function; RF role function; EF emotional function; SF social function; FA fatigue; PA pain; AP appetite loss