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. 2022 Jan 4;31(6):1829–1836. doi: 10.1007/s11136-021-03074-y

Table 3.

Summary of minimal important differences from anchor- and distribution-based methods

Anchor-based method Distribution-based method
Within-group Between-group
Improvement Deterioration Improvement Deterioration 0.2SD 0.3SD 0.5SD SEM
QL 9 − 10 11 − 8 4.4 6.6 11.0 9.3
PF 7 − 9 5 No MID 3.7 5.6 9.3 5.6
RF 15 − 17 7 − 7 5.5 8.2 13.7 11.6
EF 9 − 7 No MID − 5 4.0 6.0 10.0 7.5
SF 9 − 12 No MID − 7 4.7 7.1 11.8 8.5
FA 7 − 10 No MID − 7 4.3 6.5 10.8 8.9
PA 11 − 11 7 No MID 4.7 7.0 11.7 8.8
AP 10 − 9 No MID No MID 5.9 8.8 14.7 13.5

Symptom scales were reversed to align with functional scales; therefore, positive values represent decreases in symptom scales

SEM standard error of measurement; QL global quality of life; PF physical function; RF role function; EF emotional function; SF social function; FA fatigue; PA pain; AP appetite loss; MID minimal important difference