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. 2022 May 12;12:7867. doi: 10.1038/s41598-022-11581-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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T24 cell migrating in 0.95 mg/mL collagen. (A) and (C) Two successive images of F-actin (projected Z-stack fluorescence). White half-circles indicate regions of interest. The white arrow indicates the direction of migration whereas the white dotted arrow indicates actin-rich regions inside the nucleus. (B) and (D) show the collagen fiber 3D-displacement field around the migrating cell. For more visibility, the initial 3D cell shape is shown in grey levels and the displacement field is shown for a half space. Vector lengths and colors indicate the displacement magnitude in μm. Scale bar = 20 μm. (E) and (G) Box and whisker plots of fiber displacement vector angles versus cell migration direction for regions of interest. (F) Maximum displacement amplitudes as a function of cell-fiber distance for the actin-rich regions 1 and 4 in (A).