Table 4.

Population pharmacokinetics parameter estimates from final semi-mechanistic model

Fixed effects		Standard deviation of the random effect, ${\omega }_p$ (RSE%)	Residual error (RSE%)
Parameter	Estimate (RSE%)
FDAR8 (%)	0.9 (fixed)	a	$a_{\mathit{ADC}}$ (µg/mL) = 1.03 (6)
FDAR7 (%)	2.8 (fixed)	0.272 (fixed)	$b_{\mathit{ADC}}$ = 8.9% (3)
FDAR6 (%)	7.1 (fixed)	0.132 (fixed)	$b_{DM4}$ = 33.5% (2)
FDAR5 (%)	14.2 (fixed)	0.102 (fixed)	$b_{MeDM4}$ = 50.0% (2)
FDAR4 (%)	19.9 (fixed)	0.059 (fixed)	$b_{\mathit{NAB}}$ = 26.0% (2)
FDAR3 (%)	21.8 (fixed)	0.066 (fixed)	$a_{DA{R}_{\mathit{average}}}$ = 0.219 (6)
FDAR2 (%)	17.5 (fixed)	0.091 (fixed)	$a_{DAR{7}_{\mathit{proportion}}}$(%) = 0.517 (9)
FDAR1 (%)	8.5 (fixed)	0.091 (fixed)	$a_{DAR{6}_{\mathit{proportion}}}$(%) = 0.798 (7)
FNAB (%)	7.1 (3)	0.418 (7)	$a_{DAR{5}_{\mathit{proportion}}}$(%) = 1.47 (7)
CLADC (L/day)	0.392 (3)	0.469 (5)	$a_{DAR{4}_{\mathit{proportion}}}$(%) = 2.53 (7)
Vc (L)	3.37 (2)	0.245 (5)	$a_{DAR{3}_{\mathit{proportion}}}$(%) = 3.26 (8)
Q (L/day)	0.543 (5)	0.529 (8)	$a_{DAR{2}_{\mathit{proportion}}}$(%) = 3.48 (8)
Vp (L)	2.54 (5)	0.605 (8)	$a_{DAR{1}_{\mathit{proportion}}}$(%) = 4.58 (6)
kdec8 (/day)	0.938 (4)	0.202 (8)	$a_{{\mathit{NAB}}_{\mathit{proportion}}}$(%) = 9.93 (6)
kdec7 (/day)
kdec6 (/day)
kdec5 (/day)	0.751 (3)
kdec4 (/day)	0.525 (4)
kdec3 (/day)	0.340 (4)
kdec2 (/day)	0.181 (3)
kdec1 (/day)	0.0565 (2)
CLNAB (L/day)	0.408 (3)	0.345 (6)
CLDM4 (L/day)	240 (3)	0.365 (6)
CLMeDM4 (L/day)	0.256 (5)	0.654 (6)
FRMeDM4	0.0107 (5)	0.723 (5)

^aIIV on F_DAR8 was back calculated to ensure equilibrium among administered DAR fractions