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Terminal half-life, steady-state and accumulation ratio for each entity (after 100 mg/m2 Q2W dosing)
| Entity | Terminal half-life (days) | Steady-state | Racc for AUCTAU | Racc for Cmax |
|---|---|---|---|---|
| SAR408701 | 8.8 | Cycle 3 | 1.4 | 1.3 |
| DM4 | 8.7a | Cycle 3 | 1.1 | 1.1 |
| MeDM4 | 8.7a | Cycle 3 | 1.3 | 1.3 |
| NAB | 12.2 | Cycle 6 | 2.9 | 2.5 |
aApparent terminal half-life: formation limited kinetic for DM4 and MeDM4
