Table 7.

Typical exposure parameters at cycle 1 for each entity (after 100 mg/m² Q2W dosing)

Entity	Cycle 1 AUCTAU, i (µM.day)	$\frac{{\text{AUC}}_{\text{TAU},\text{i}}}{{\text{AUC}}_{\text{TAU},\text{SAR}408,701}}$	Cycle 1 Cmax, i (µM)	$\frac{{\text{C}}_{\text{max},\text{i}}}{{\text{C}}_{\text{max},\text{SAR}408,701}}$
SAR408701	250	1	0.326	1
DM4	1.00	0.40%	0.00208	0.64%
MeDM4	8.69	3.5%	0.00610	1.9%
NAB	32.5	13%	0.0249	7.6%