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. 2022 May 12;5:455. doi: 10.1038/s42003-022-03380-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Interaction plot illustrating differences across inv-8p23.1 genotypes in the association between cg01489256 (TDH) methylation and meat intake (expressed in servings per week). Methylation means the given meat-intake status and inversion genotype are represented with their 95% confidence intervals (N = 1009). b Forest plot showing the meta-analysis effect estimates of inv-8p23.1–meat-intake interaction on cg01489256 methylation across HELIX cohorts. c Interaction plot illustrating differences across inv-8p23.1 genotypes in the association between cg26020513 (GATA4) methylation and manganese (N = 1009). d Forest plot showing the meta-analysis effect estimates of inv-8p23.1–manganese interaction on cg26020513 methylation across HELIX cohorts. e Interaction plot illustrating differences across inv-8p23.1 genotypes in the association between cg08196601 (TRMT9B) methylation and parental smoking (N = 1009). f Forest plot showing the meta-analysis effect estimates of the inv-8p23.1–parental smoking interaction on cg08196601 methylation across HELIX cohorts. Blue points and lines illustrate noninverted homozygous (N/N), yellow illustrates heterozygous (N/I), and orange illustrates inverted homozygous (I/I) individuals. The error bar represents one standard deviation.