Table 5 –

Five-Year Developmental Outcomes

	High-dose	Standard-dose	P value
WPPSI-III, m ± SD	N=21	N=25
General cognition score	90.4 ± 15.4	87.0 ± 11.2	0.39
Verbal cognition score	89.4 ± 16.3	86.7 ± 12.4	0.54
Non-verbal cognition score	96.0 ± 16.8	91.7 ± 16.1	0.39
General cognitive delay1, n (%)	7 (33)	11 (44)	0.55
General cognitive impairment2, n (%)	2 (10)	1 (4)	0.59
CELF-P2, m ± SD	N=21	N=25
Language score	89.0 ± 19.4	87.6 ± 14.6	0.79
Language delay1, n (%)	8 (38)	9 (36)	1
Language impairment2, n (%)	4 (19)	3 (12)	0.69
MABC-2, m ± SD	N=20	N=24
Total Motor score	5.4 ± 3.7	4.8 ± 2.8	0.53
Motor delay3, n (%)	13 (65)	20 (83)	0.16
Motor impairment4, n (%)	12 (60)	15 (63)	1
Shape School, m ± SD	N=17	N=20
Cognitive inhibition efficiency	0.72 ± 0.49	0.54 ± 0.30	0.18
Failed cognitive inhibition condition, n (%)	1 (6)	2 (10)	1
Set shifting efficiency	0.13 ± 0.29	0.13 ± 0.22	0.97
Failed set shifting condition, n (%)	4 (24)	4 (20)	1
Inhibition-shifting switch efficiency	0.25 ± 0.31	0.22 ± 0.29	0.75
Failed inhibition-shifting switch condition, n (%)	4 (24)	5 (25)	1
CBCL/1.5–5, m ± SD	N=18	N=24
Internalizing t-score	45.8 ± 13.5	50.5 ± 16.7	0.33
Internalizing problems5, n (%)	2 (11)	5 (21)	0.45
Externalizing t-score	45.0 ± 13.7	49.9 ± 17.2	0.33
Externalizing problems5, n (%)	2 (11)	5 (21)	0.45
SRS-2, m ± SD	N=21	N=25
Social Communication and Interaction t-score	53.2 ± 11.4	56.2 ± 11.6	0.39
Restricted Interests and Repetitive Behavior t-score	54.9 ± 15.3	57.1 ± 13.5	0.60
High levels of autistic traits5, n (%)	5 (24)	7 (28)	0.68

¹Delay defined as a standardized score < 85

²Impairment defined as a standardized score < 70

³Delay defined as a standardized score ≤ 15^th percentile or unable to complete

⁴Impairment defined as a standardized score ≤ 5^th percentile or unable to complete

⁵Defined as composite t-score > 60