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. Author manuscript; available in PMC: 2023 May 11.
Published in final edited form as: Chem Rev. 2022 Mar 11;122(9):8884–8910. doi: 10.1021/acs.chemrev.1c00773

Figure 7. Proposed flipping mechanism and membrane potential-driven resetting of MurJ.

Figure 7.

(a) Model showing proposed steps in the transport cycle. Structures were obtained from the PDB (inward-closed: 6NC6; inward-open: 6NC7; inward-occluded: 6NC8; outward-open: 6NC9). (b) A sodium ion (yellow sphere) is found in the outward-open structure, coordinated by TMs 7, 11 and 12. The coordinating residues are shown in the close-up. (c) The E57-R352 ion pair forms the thin gate. The Lipid II-binding pocket is indicated on the inward-occluded structure.