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. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: Pediatr Res. 2021 Nov 13;92(3):712–720. doi: 10.1038/s41390-021-01832-9

Figure 2: Comparison analysis of dysregulated canonical pathways in PIA males and females.

Figure 2:

(A) Males showed similar downregulation of pathways regardless of degree of anemia whereas females (B) showed dysregulation following sPIA only. Both sexes showed dysregulation of neuroinflammatory and cAMP-mediated signaling; directionality was sex-dependent for neuroinflammatory signaling, downregulation predicted for males and upregulation predicted for females.