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. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: Pediatr Res. 2021 Nov 13;92(3):712–720. doi: 10.1038/s41390-021-01832-9

Figure 3: STAT1 dysregulation across PIA severity in males and females.

Figure 3:

sPIA females are predicted to have a significant upregulation of the STAT1 pathway. sPIA and mPIA males showed a similar dysregulation but opposite directionality. Red- and green-filled shapes indicate up- and downregulation of genes, respectively, with brighter color indicating larger differences. Orange lines indicate activation; blue lines indicate inhibition; yellow lines indicate findings inconsistent with the state of downstream activity; gray lines indicate that the effect is not predicted.