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. Author manuscript; available in PMC: 2022 Oct 18.
Published in final edited form as: Pediatr Res. 2021 Nov 13;92(3):712–720. doi: 10.1038/s41390-021-01832-9

Figure 5: CREB1 dysregulation in sPIA males and females.

Figure 5:

CREB1 expression is predicted to be downregulated in both sPIA males (z score −3.38) and females (z-score −3.82) with more downstream genes being affected in females (36 v 93 genes). Red- and green-filled shapes indicate up- and downregulation of genes, respectively, with brighter color indicating larger differences. Orange lines indicate activation; blue lines indicate inhibition; yellow lines indicate findings inconsistent with the state of downstream activity; gray lines indicate that the effect is not predicted.